Open Access
LogoLogo
About JournalArchiveSearchFor AuthorsFor ReviewersHelpOnline-Submission
Archive
Vol.48, No.6, 2014
Current Issue
Archive (2009~
Archive-the Korean Journal of Pathology(1967~2008)
Archive-the Korean Journal of Cytopathology(1990~2008)
Most Read Articles
  Vol.26, No.6:593-600, December 1992
Histopathologic Study of Post-irradiation Specimen

Lee Hye-Kyung, Lee Kwang-Min, Chung Dong-Kyu, Kim Su-Gon

Department of Pathology and Therapeutic Radiology Presbyterian Medical Center, Jeonju 560-250, Korea

The number of post-irradiated surgical specimen appears to have risen in recent years due to the increasing utiliz ation of radiotherapy for cancer patients. Radiation therapy damages cells by its effects on the deoxyribonucleic acid and the spectrum of injury ranges from acute self-limited lesion to irreversible chronic lesion. We reviewed 24 cases of post-irradiated specimen and thought that time interval is the main factor influencing the morphologic change. Within six weeks, the individual cytologic changes such as biz arre nuclei, altered nucleus/cytoplasm ratio, amphophilic and vacuolated cytoplasm are noted. Chronic injury resulting from progressive changes in the fibrovascular tissue of the radiated area occur in six months after the initial course of radiation and the vascular changes of intimal thickening and fibrosis, foamy histiocytes within media, periadventital fibrosis and chronic inflammatory cells infiltration are present. Althouhg above mentioned finding are not pathognomonic, we thought them quite constant nd reproducible characteristics of radiation injury.
Key Words : Radiation injury, Radiation therapy, Fibrovascular change

Copyright(c) 2008 By the Korean Society of Pathologists & the Korean Society for Cytopathology
Room 1209 Gwanghwamun Officia, 163 Sinmunno 1-ga, Jongno-gu, Seoul 110-999, Korea
Tel: +82-2-795-3094, Fax: +82-2-790-6635, E-mail: jptm@kams.or.kr.
#406 Lilla Swami Bldg, 391-18, Yangjae-dong, Seocho-gu, Seoul 137-130, Korea
Tel: +82-2-593-6943 Fax: +82-2-593-6944, E-mail: cytopathology@hanmail.net