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Vol.48, No.6, 2014
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Archive-the Korean Journal of Pathology(1967~2008)
Archive-the Korean Journal of Cytopathology(1990~2008)
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  Vol.16, No.1:47-51, March 2005
Case reports
Fine Needle Aspiration Cytology of the Plasmablastic Lymphoma in Human Immunodeficiency Virus(HIV) Negative Patient -A Case Report-

Hyang-Im Lee, Hyun-Ryung Koo, Eun-Mee Han, Gyung-Yub Gong, Chul-Won Suh, Min-Hee Ryu, Yoon-Goo Kang, Chan-Jeong Park, Joo-Ryung Huh

Department of Pathology, Internal Medicine, and Clinical Pathology, Asan Medical Center, Ulsan University, Seoul ; Department of Pathology, Ansan Hospital, Korea University, Ansan, Korea

Plasmablastic lymphoma (PBL) is a recently described aggressive B-cell neoplasm, which usually manifestsas a localized disease of the oral mucosa in individuals infected with human immunodeficiency virus (HIV).Recently, we encountered a case of plasmablastic lymphoma manifesting in the left maxillary sinus and cervicallymph node of a previously healthy HIV-negative man, 48 years of age. we conducted a fine-needle aspirationsmear of the cervical lymph node, and this was found to be highly cellular with numerous large cells exhibitingeccentrically positioned nuclei, prominent nucleoli, and moderate quantities of basophilic cytoplasm. A biopsy ofthe mass in the maxillary sinus evidenced diffuse growth of similar plasmablastic cells. These tumor cells werenegative for the leukocyte common antigens, CD20, CD3, CD30, and EMA. However, the cells tested positivefor CD79a and CD138/syndecan-1. The tumor cells also exhibited L-light-chain restriction. The Ki-67proliferation index was measured at almost 100%. The patient was diagnosed with plasmablastic lymphoma.After three cycles of combination chemotherapy and radiotherapy, the patient went into complete remission, andcurrently remains in this state.
Key Words : Plasmablastic lymphoma, HIV, Fine needle aspiration cytology

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