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Vol.48, No.6, 2014
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Archive (2009~
Archive-the Korean Journal of Pathology(1967~2008)
Archive-the Korean Journal of Cytopathology(1990~2008)
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  Vol.16, No.1:18-24, March 2005
Original articles
The Usefulness of Concomitant High-Risk Human Papillomavirus Test and Colposcopy in Combination with the Papanicolaou Test in ASCUS Patients

Min-Kyung Kim, Jin-Hee Sohn, Chul-Hwan Kim, Jong-Sang Choi

Department of Pathology, Kangbuk Samsung Hospital, College of Medicine, Sungkyunkwan University, Department of Pathology, College of Medicine, Korea University, Seoul, Korea

The objective of this study was to ascertain whether or not the high-risk human papillomavirus (HPV) test,when coupled with Papanicolaou (Pap) smears, would prove useful in the screening and management of patientsin whom abnormal Pap smear results had been obtained. Concomitant high-risk HPV detection using the hybridcapture II test and colposcopy with a Pap smear were performed with 176 patients, all of whom had beenscreened for both cervical carcinoma and precancerous lesions. We concomitantly performed colposcopies onthese patients. Upon the follow-ups, the histologic diagnoses of these patients were confirmed via either biopsyor hysterectomy. The rate of high-risk HPV detection was correlated with cytologic diagnoses and colposcopicfindings. The group composed of the high-risk HPV-positive ASCUS patients exhibited a 55.7% rate of cervicalintraepithelial neoplasia (CIN), a significantly higher rate than the 7.5% result obtained in the high-risk HPVnegativeASCUS group. HPV test showed high sensitivity (87%) and low specificity (62.6%) in detection of CINand colposcopy also showed high sensitivity (88%) and low specificity (22%). Any combination of these testsimprove sensitivity, but not specificity. High-risk HPV tests, when coupled with Pap smears, constituted a usefultriage approach with regard to colposcopy-directed biopsies in patients in whom a cytologic diagnosis of ASCUShad been rendered.
Key Words : Human papillomavirus, ASCUS, Colposcopy

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