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Vol.48, No.6, 2014
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Archive-the Korean Journal of Pathology(1967~2008)
Archive-the Korean Journal of Cytopathology(1990~2008)
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  Vol.16, No.1:10-17, March 2005
Original articles
Clinical Efficacy of Manual Liquid-Based Cervicovaginal Cytology Preparation: Comparative Study with Conventional Papanicolaou Test

Jong-Myoung Park, Jong-Gi Lee, In-Soo Suh

Department of Cytopathology, Sung-Yoon Reference Laboratory, Department of Pathology, Kyungpook National University School of Medicine, Daegu, Korea

This study was performed to compare manual liquid-based preparation with conventional Papanicolaou testsin view of the cytologic diagnoses and specimen adequacy. The specimens of 5,979 women from 33 localclinics and 1 general hospital were prepared by both manual liquid-based preparation and conventionalPapanicolaou test. The cytologic diagnoses and specimen adequacy were evaluated in Department of Pathologyin Kyoungpook National University School of Medicine. A conventional Papanicolaou test was always preparedfirst, after that residual material on the sampling device was rinsed into a liquid preservative, and thenthin-layer slides were prepared using manual method of liquid-based cervicovaginal cytology. Conventional andliquid-based slides were read independently, and cytologic diagnoses and specimen adequacy were classifiedusing the Bethesda System. Of the cases, 5,763 (96.3%) had the same interpretation, and there was nosignificant diagnostic difference in 5,853 (97.8%) cases. When evaluating cases with more than one diagnosticclass difference, the manual liquid-based preparation demonstrated a statistically significant overall improvement(2.1%) in the detection of squamous intraepithelial lesion and invasive cancer. Using manual method of liquidbasedpreparation, there was 14.1% reduction in unsatisfactory slides through excellent cellular presentations. Inconclusion, the manual liquid-based preparation produces standardized quality, superior sensitivity and improvedadequacy as compared to the conventional method.
Key Words : Clinical efficacy, Manual liquid-based preparation, Conventional Papanicolaou test

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