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Archive-the Korean Journal of Pathology(1967~2008)
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  Vol.46, No.6:606-610, December 2012
Case reports
Cervical Lymphadenopathy Mimicking Angioimmunoblastic T-Cell Lymphoma after Dapsone-Induced Hypersensitivity Syndrome

Min Young Rim· Junshik Hong· Inku Yo · Hyeonsu Park· Dong Hae Chung1 · Jeong Yeal Ahn2· Sanghui Park3 · Jinny Park· Yun Soo Kim· Jae Hoon Lee

Departments of Internal Medicine, 1Pathology, and 2Laboratory Medicine, Gachon University Gil Hospital, Gachon University of Medicine and Science, Incheon; 3Department of Pathology, Ewha Womans University School of Medicine, Seoul, Korea

A 36-year-old woman presented with erythematous confluent macules on her whole body with fever and chills associated with jaundice after 8 months of dapsone therapy. Her symptoms had developed progressively, and a physical examination revealed bilateral cervical lymphadenopathy and splenomegaly. Excisional biopsy of a cervical lymph node showed effacement of the normal architecture with atypical lymphoid hyperplasia and proliferation of high endothelial venules compatible with angioimmunoblastic T-cell lymphoma. However, it was assumed that the cervical lymphadenopathy was a clinical manifestation of a systemic hypersensitivity reaction because her clinical course was reminiscent of dapsone-induced hypersensitivity syndrome. A liver biopsy revealed drug-induced hepatitis with no evidence of lymphomatous involvement. Intravenous glucocorticoid was immediately initiated and her symptoms and clinical disease dramatically improved. The authors present an unusual case of cervical lymphadenopathy mimicking angioimmunoblastic T-cell lymphoma as an adverse reaction to dapsone.
Key Words : Pseudolymphoma; Dapsone therapy

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