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 Vol.46, No.2:205-209, April 2012 |
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 Case reports
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http://dx.doi.org/10.4132/KoreanJPathol.2012.46.2.205
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Invasive Cribriform Carcinoma Arising in Malignant Phyllodes Tumor of Breast: A Case Report
Yoomi ChoiㆍKyoung YulㆍLeeMin Hye JangㆍHyesil Seol1ㆍSung-Won Kim2ㆍSo Yeon Park3
Department of Pathology, Seoul National University Hospital, Seoul National University College of Medicine; 1Department of Pathology, Korea Institute of Radiological and Medical Sciences, Seoul; Departments of 2Surgery and 3Pathology, Seoul National University Bundang Hospital, Seoul National University College of Medicine, Seongnam, Korea
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Phyllodes tumor is an uncommon fibroepithelial neoplasm of the breast. And it is characterized by expanded stroma with increased cellularity and elongated epithelium-lined clefts. Mammary carcinomas within phyllodes tumors have been rarely reported. To date, however, no reports have described the invasive cribriform carcinoma arising in malignant phyllodes tumor. Here, we report a 62-year-old woman who presented with a large breast mass. Microscopically, the mass was a typical malignant phyllodes tumor showing well developed leaf-like architecture and stromal overgrowth with high cellularity and nuclear pleomorphism. In a portion of the tumor, however, the epithelial component showed a cribriform pattern of proliferation in the absence of myoepithelial cells, suggestive of the invasive cribriform carcinoma. To our knowledge, this is rare and it is difficult to make a differential diagnosis of it. Here, we report our case with a review of literatures. |
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Key Words : Invasive carcinoma; Phyllodes tumor; Breast; Cribriform |
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