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Vol.48, No.3, 2014
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Archive-the Korean Journal of Pathology(1967~2008)
Archive-the Korean Journal of Cytopathology(1990~2008)
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  Vol.46, No.2:205-209, April 2012
Case reports
http://dx.doi.org/10.4132/KoreanJPathol.2012.46.2.205
Invasive Cribriform Carcinoma Arising in Malignant Phyllodes Tumor of Breast: A Case Report

Yoomi ChoiㆍKyoung YulㆍLeeMin Hye JangㆍHyesil Seol1ㆍSung-Won Kim2ㆍSo Yeon Park3

Department of Pathology, Seoul National University Hospital, Seoul National University College of Medicine; 1Department of Pathology, Korea Institute of Radiological and Medical Sciences, Seoul; Departments of 2Surgery and 3Pathology, Seoul National University Bundang Hospital, Seoul National University College of Medicine, Seongnam, Korea

Phyllodes tumor is an uncommon fibroepithelial neoplasm of the breast. And it is characterized by expanded stroma with increased cellularity and elongated epithelium-lined clefts. Mammary carcinomas within phyllodes tumors have been rarely reported. To date, however, no reports have described the invasive cribriform carcinoma arising in malignant phyllodes tumor. Here, we report a 62-year-old woman who presented with a large breast mass. Microscopically, the mass was a typical malignant phyllodes tumor showing well developed leaf-like architecture and stromal overgrowth with high cellularity and nuclear pleomorphism. In a portion of the tumor, however, the epithelial component showed a cribriform pattern of proliferation in the absence of myoepithelial cells, suggestive of the invasive cribriform carcinoma. To our knowledge, this is rare and it is difficult to make a differential diagnosis of it. Here, we report our case with a review of literatures.
Key Words : Invasive carcinoma; Phyllodes tumor; Breast; Cribriform

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