Open Access
LogoLogo
About JournalArchiveSearchFor AuthorsFor ReviewersHelpOnline-Submission
Archive
Vol.48, No.5, 2014
Current Issue
Archive (2009~
Archive-the Korean Journal of Pathology(1967~2008)
Archive-the Korean Journal of Cytopathology(1990~2008)
Most Read Articles
  Vol.29, No.3:393-398, June 1995
Etc
A Case of Malignant Lymphoma Misdiagnosed as Focal Lymphoid Hyperplasia in the Esophagus

Chung Sook-Keum, Ko Young-Hyeh, Park Chan-Keum, Lee Jung-Dal

Department of Pathology, Hanyang University College of Medicine, Seoul 133-792, Korea, and Kosin University

Esophageal involvement by malignant lymphoma is extremely rare. A case of follicular lymphoma of the esophagus, misdiagnosed as focal lymphoid hyperplasia (pseudolymphoma) in a 72-year-old man is presented. The esophagogram revealed diffuse narrowing of the lumen in the middle and distal portion without ulceration. The resected esophagus showed mural thickening without any remarkable mucosal change. Microscopically, the esophagus showed scattered follicular lymphoid aggregates in the submucosa, extending into periadventitial fat tissue. Most follicles were devoid of germinal center and consisted of loosely aggregated small cleaved cells without atypia. The surrounding stroma of the submucosa showed dense fibrosis entrapping the infiltrating small lymphocytes in a "indian-file" appearance. There were some reactive follicles with germinal center. In the lamina propria, many plasma cells and a few eosinophils were infiltrated. The gene rearrangement study showed rearranged band for Jk probe which confirmed monoclonal B-cell nature of infiltrated small lymphoid cells. The small cleaved lymphocytes arranged in follicles were positive for L26 and bcl-2 protein. This case demonstrated the necessity of immunophenotypic and gene rearrangement study in the diagnosis of pseudolymphoma in the digestive tract.
Key Words : Malignant lymphoma, Pseudolymphoma, Immunophenotyping, Gene rearrangement, Esophagus

Copyright(c) 2008 By the Korean Society of Pathologists & the Korean Society for Cytopathology
Room 1209 Gwanghwamun Officia, 163 Sinmunno 1-ga, Jongno-gu, Seoul 110-999, Korea
Tel: +82-2-795-3803, 3094, Fax: +82-2-790-6635, E-mail: kjpath@kams.or.kr.
#406 Lilla Swami Bldg, 391-18, Yangjae-dong, Seocho-gu, Seoul 137-130, Korea
Tel: +82-2-593-6943 Fax: +82-2-593-6944, E-mail: cytopathology@hanmail.net