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Vol.48, No.6, 2014
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Archive (2009~
Archive-the Korean Journal of Pathology(1967~2008)
Archive-the Korean Journal of Cytopathology(1990~2008)
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  Vol.43, No.5:478-481, October 2009
Case reports
http://dx.doi.org/10.4132/KoreanJPathol.2009.43.5.478
Eosinophilic Fasciitis Associated with Overlying Intraepidermal Blister Formation - A Case Report

Na Rae Kim, Dong-Hae Chung, Seung-Yeon Ha

Department of Pathology, Gachon University Gil

Eosinophilic fasciitis is a scleroderma-like disease and it may present with paraneoplastic syndrome
or as an isolated form of the disease. We report here on a case of eosinophilic fasciitis
in a 20-year-old woman who presented with an abrupt onset of subcutaneous limb swelling
and peripheral eosinophilia. Pathologically, the specimen was characterized by acute inflammation
and thickening of the collagen bundles in the reticular dermis and superficial muscle
fascia in addition to the overlying intraepidermal blisters that contained many eosinophils. Eosinophils,
some lymphocytes and plasma cells were infiltrated in the superficial muscle fascia
and subcutaneous fat. The diagnosis of eosinophilic fasciitis was confirmed by biopsy. It is
intriguing that eosinophilic fasciitis showed the microscopic findings of intraepidermal blister
with predominant inflammation, and the patient showed a good response to steroid therapy.
Key Words : Eosinophilia; Fasciitis; Panniculitis; Blister

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