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Vol.48, No.6, 2014
Current Issue
Archive (2009~
Archive-the Korean Journal of Pathology(1967~2008)
Archive-the Korean Journal of Cytopathology(1990~2008)
Most Read Articles
  Vol.43, No.5:453-457, October 2009
Original articles
Histologic Correlation of Atypical Glandular Cells in Cervical Smears

Yi Kyeong Chun, Sung Ran Hong, Hye Sun Kim, Ji Young Kim, Hy Sook Kim

Background : The study evaluated the histologic correlation and clinical significance of atypical
glandular cells (AGC) detected either on conventional smears (CS) or liquid-based cytology

Methods : Two hundred and seventy-seven (0.11%) of 261,925 cervical smears
were interpreted as AGC by the Bethesda system 2001 from January 2006 to December 2008.
Cytohistological correlation was performed on 192 cases.

Results : The prevalence of AGC
was 0.07% and 0.13% for CS and LBC smears, respectively. Distribution of AGC subcategories
were as follows: atypical endometrial cells 53.8%, atypical endocervical cells 22.7%,
atypical glandular cells 19.5%, atypical endocervical cells favoring neoplasia 2.2%, and atypical
glandular cells favoring neoplasia 1.8%. Fifty-nine (27.4%) of 192 patients were confirmed
as having clinically significant lesions comprising endometrial adenocarcinoma (12.5%), endometrial
hyperplasia (6.0%), cervical adenocarcinoma (2.3%), high-grade squamous intraepithelial
lesion (HSIL) (1.9%), low-grade SIL (1.9%), adenocarcinoma in situ (1.4%), or ovarian
metastasis (1.4%). Conclusion : Compared with CS, LBC was presently associated with a
higher prevalence of AGC. Histologic follow-up showed a very low HSIL rate compared to
other studies. Endometrial adenocarcinoma was the most common malignant lesion detected
because of increasing prevalence of endometrial adenocarcinoma, concentration on endometrial
cytology, and introduction of LBC.
Key Words : Atypical glandular cells; Cytohistologic correlation

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