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Vol.48, No.6, 2014
Current Issue
Archive (2009~
Archive-the Korean Journal of Pathology(1967~2008)
Archive-the Korean Journal of Cytopathology(1990~2008)
Most Read Articles
  Vol.43, No.5:448-452, October 2009
Original articles
Comparison of Cytologic Evaluation between Conventional Method and CellprepPlus􀋓 Liquid-Based Cytology in Body Fluid

Ji Hae Koo, Ho-Chang Lee, Hyung Geun Song, Hye-Suk Han, Ki Hyeong Lee, Kang Hyeon Choe, Ki Man Lee, Ok-Jun Lee

Background : Assessment of body fluid cytology is a useful means of evaluating a metastatic
tumor. Liquid-based cytology (LBC) has been developed as a replacement for the conventional
Papanicolaou (CP) test. This study was performed to compare CellprepPlus􀋓 LBC with CP
in cytologic diagnosis.

Methods : Body fluid samples (n=188, including 72 peritoneal fluid and
116 pleural fluid samples) were divided equally and analyzed by both CellprepPlus􀋓 and CP.

Results : CellprepPlus􀋓 revealed distributed thin layers of non-overlapping cells. All Cellprep-
Plus􀋓 preparations were adequate, while 18 (9.57%) CP preparations were inadequate. The
respective diagnostic rates of CellprepPlus􀋓 and CP were 75.0% and 76.1% negative, 10.6%
and 6.38% atypical, 5.85% and 2.66% suspicious, and 8.51% and 5.32% malignant. Of the 58
confirmed cases, the sensitivity of CellprepPlus􀋓 and CP was 94.4% and 73.3%, respectively,
and the negative predictive value was 97.2% and 87.9%, respectively. Conclusions :
CellprepPlus􀋓 LBC has better sensitivity and negative predictive value, and produces higher
quality slide preparations than than CP, making it suitable as in screening of body fluid as a
cytologic diagnostic tool.
Key Words : Body fluids; Cytology; Neoplasm metastasis

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