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Vol.48, No.6, 2014
Current Issue
Archive (2009~
Archive-the Korean Journal of Pathology(1967~2008)
Archive-the Korean Journal of Cytopathology(1990~2008)
Most Read Articles
  Vol.43, No.5:441-447, October 2009
Original articles
Clinicopathologic Characteristics of Endometrial Adenocarcinomas in Young Women

Gawon Choi, Jeong Won Kim, Shin Kwang Khang, Kyu Rae Kim

Background : Despite an increased incidence of endometrial carcinomas in young Korean
women, clinicopathologic characteristics and treatment outcomes have not been analyzed.

Methods : We investigated clinicopathologic characteristics of endometrial carcinoma in 48
women who were under the age of 40 in order to determine treatment guideline. Results :
According to the criteria of the Korean Society for Obesity, 70.8% of study patients were overweight
or obese, with an average body mass index (BMI) of 26.0 kg/m2. Twelve patients received
progesterone treatment only, and 6 of them later had successful pregnancies. The histologic
subtype was endometrioid adenocarcinoma in all patients. FIGO stages were 1A (41.7
%), 1B (47.1%), IIA (2.8%), IIB (2.8%), IIIA (2.8%), and IIIC (2.8%). FIGO grades were grade
1 (79%) or 2 (21%). The average depth of invasion, excluding stage 1A, was 4.6 mm in the
hysterectomy specimens. Two patients were given post-operative radiation treatment and 4
were treated with chemotherapy. All but one case had an uneventful postoperative course
during follow-up.

Conclusions : A majority of endometrial carcinomas in young Korean women
were associated with an early FIGO stage, favorable histologic subtype and grades, and a
good prognosis. Progesterone treatment with close observation was a successful treatment
option in a selected group of young patients.
Key Words : Carcinoma; Endometrium; Young age; Progesterone therapy; Pregnancy

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