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Vol.48, No.6, 2014
Current Issue
Archive (2009~
Archive-the Korean Journal of Pathology(1967~2008)
Archive-the Korean Journal of Cytopathology(1990~2008)
Most Read Articles
  Vol.43, No.5:435-440, October 2009
Original articles
Predictive Significance of KRAS and Tau for Chemoresponse in Advanced Non-Small-Cell Lung Cancer

Jinyoung Yoo, Byoung Yong Shim, Chang Young Yoo, Seok Jin Kang, Kyo Young Lee

Background : Taxane-platinum combinations are often used as first-line treatments for patients
with advanced non-small cell lung cancer (NSCLC). Response to chemotherapy for these
patients is still poor. The aim of our study was to investigate, for this disease, whether KRAS
and Tau proteins affect responses to taxane-platinum combinations.

Methods : Expression
of KRAS and Tau was examined immunohistochemically in 71 tumor samples obtained from
patients with stage IIIB or IV NSCLC prior to combination therapy. Expression was correlated
with tumor responses.

Results : The response rate was 55% (39 of 71). KRAS and Tau were
expressed in seven (10%) and 31 (44%) patients, respectively. All seven KRAS-positive patients
were non-responders (p=0.014). Among Tau-positive patients , 35% (11 of 31) responded to
therapy, whereas a partial response was observed in 70% (28 of 40) of Tau-negatives (p=
0.045). Two were positive for both, and they were non-responders. In patients negative for
both, the response rate was 71% (25 of 35) (p=0.012).

Conclusions : Expression of KRAS and
Tau are significantly correlated with poor responses to this combination therapy in advanced
NSCLC patients, and may be a useful marker for chemoresistance.
Key Words : Carcinoma, Non-Small-Cell Lung; Chemotherapy; KRAS protein, human; Tauprotein

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