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Vol.48, No.6, 2014
Current Issue
Archive (2009~
Archive-the Korean Journal of Pathology(1967~2008)
Archive-the Korean Journal of Cytopathology(1990~2008)
Most Read Articles
  Vol.43, No.5:408-412, October 2009
Original articles
http://dx.doi.org/10.4132/KoreanJPathol.2009.43.5.408
Significance of the Expression of Cathepsins B, H, & L in Colonic Epithelial Neoplasms

Jae-Young Sim, Mi-Ja Lee, Keun-Hong Kee



Background : Cathepsin is associated with tumorigenesis, tumor invasion and metastasis
through its ability to induce degradation of extracellular matrix components.

Methods : To
investigate the correlation between cathepsin expression and tumor progression, invasion
depth or nodal metastasis, immunohistochemical staining for cathepsins B, H and L were done
on 20 hyperplastic polyps, 48 adenomas, and 67 adenocarcinomas of the colon. Evaluation
of the expression of cathepsins B, H and L was based on the percentage of neoplastic cells
that stained positive for any given cathepsin.

Results : Cathepsin B expression was significantly
higher in adenocarcinomas than adenomas (29.33 vs 5.48%), but was not associated
with the degree of differentiation, depth of invasion and nodal status of the tumors. Expression
of cathepsins H and L was absent or low in both adenomas and adenocarcinomas. Conclusions
: We suggest that cathepsin B is involved in progression of a subset of colonic adenomas,
while cathepsins H and L are not.
Key Words : Cathepsin; Colon; Adenoma; Adenocarcinoma

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