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Vol.48, No.6, 2014
Current Issue
Archive (2009~
Archive-the Korean Journal of Pathology(1967~2008)
Archive-the Korean Journal of Cytopathology(1990~2008)
Most Read Articles
  Vol.43, No.5:393-399, October 2009
Original articles
Enhanced Protein Expression of Signal Transducer and Activator of Transcription 3 and Protein Kinase Substrate p36 in Hepatocellular Carcinoma

Hongxiu Han, Si-Hyong Jang, Chan Kum Park

Department of Pathology, College of Medicine, Hanyang University

Background : Signal transducers and activators of transcription 3 (STAT3) and protein kinase
substrate p36 may be involved in cell proliferation, differentiation and growth.

Methods : Immunohistochemistry
for STAT3 and p36 was performed in 46 patients with hepatocellular
carcinoma (HCC).

Results : STAT3 staining was present in the cytoplasm and/or nucleus,
while p36 staining was present in the nucleus. STAT3 and p36 expression occurred in 78.3%
(36/46) and 47.8% (22/46) of HCC patients, respectively. However, no correlation was found
between STAT3 and p36 protein expression (p>0.05). Enhanced expression of STAT3 was
negatively correlated with portal vein invasion (p=0.033). Expression of STAT3 in the nucleus
was correlated with tumor grade (p=0.004). Enhanced expression of p36 was correlated with
tumor grade (p=0.031). HCC was correlated with HBV infection (p=0.032). The patients’ 5-
year survival was related to expression of p36 (p=0.044), but not to total STAT3 or nuclear
STAT3 (p>0.05).

Conclusions : The enhanced expression of STAT3 in the nucleus and the
enhanced expression of p36 are associated with the aggressive phenotype of HCC. Enhanced
p36 expression may contribute to poor survival of patients with HCC.
Key Words : Hepatocellular carcinoma; STAT3 transcription factor; p36

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